The patient was initially revealed a left atrium mass by 2-dimensional transthoracic echocardiography. Patient concerns:Ī 49-year-old woman presented to our hospital with 2 weeks of gradual onset of dyspnea on exertion, dry cough and subacute fever. Herein, we reported a case of left atrial spindle cell sarcoma diagnosed and treated by a multidisciplinary approach, and retrospectively reviewed other reported cases. Ĭardiac primary spindle cell sarcoma is 1 of the rarest cardiac malignancies, with only a few cases reported so far.
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Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website ( This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Supplemental digital content is available for this article. The authors have no conflicts of interest to disclose.Īll data generated or analyzed during this study are included in this published article [and its supplementary information files. Left atrial spindle cell sarcoma: a case report and literature review.
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How to cite this article: Qin J, Li R, Ma F, Li H, Fang Z, Fei Y. China (e-mail: ).Ībbreviations: CMR = cardiac magnetic resonance, CT = computed tomography, PCT = polychemotherapy, TTE = transthoracic echocardiography. ∗Correspondence: Jin Qin, Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. In response to an injury, infection, or other immune response, the spindle cells of connective tissue will begin dividing to heal the affected area if the tissue is predisposed to spindle cell cancer, the high cellular turnover may result in a cell mutating, becoming cancerous, and forming a tumor.ADivision of Cardiology, Department of Internal MedicineĬDepartment of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. Normal spindle cells are a naturally occurring part of the body's response to injury. In these cases, prognosis is grim and chemotherapy and radiation are the only methods of controlling the cancer.Ī variety of factors influence the incidence of spindle cell sarcoma, including genetic predisposition, but it may also be caused by a combination of other factors, including injury and inflammation in patients who are already thought to be predisposed to such tumors. The prognosis for a stage 1 tumor excision is usually fairly optimistic, but if the tumor progresses to levels 2 and 3, prognosis worsens, due to tumor cells' likely having spread to other parts of the body, including nearby healthy tissues, or to system-wide locations that include the lungs, kidneys, and liver. As such, at Stage 1, the tumor is usually treated by excision, which includes wide margins of healthy-looking tissue, followed by thorough biopsy, and additional excision, if necessary. However, it may develop cancerous traits that can only be detected through microscopic examination or cell-level molecular analysis.
At first, the lump is, small in size, as the tumor exists in Stage 1, and will not necessarily expand beyond its encapsulated form. The tumors generally begin in layers of connective tissue, as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size. Spindle cell sarcoma is a type of connective tissue cancer.